Dr. Andrews led the team of scientists and researchers that discovered the enzyme telomerase. Telomerase rebuilds your telomeres, the genetic ends of your chromosomes. They are the genetic clock. They tell each cell how old to behave. Each time your cells divide, your telomeres get shorter. And when your telomeres run down, cell division stops and your life ends. Never before has it been possible to reverse this process. For the first time in medical history we have the ability to activate or “switch on” the telomerase enzyme. It’s in every cell of your body but is often turned off. Telomerase rebuilds your telomeres – meaning your cells could actually get younger as time goes by. Today you’ll read Dr Andrew’s take on this remarkable technology and how you can apply it to your own life. Here’s an excerpt of our conversation… Dr. Sears: What’s the driving force behind your achievements in anti-aging? Dr. Andrews: My original mission was – and still is – to extend my own life. But my interest in aging goes all the way back to my high school days. Back then I realized the environment had an impact on aging but felt the free radical theory was only part of the puzzle – not the main reason why we age. Whenever I looked at human aging – or even the way plants and animals age – I always felt there was some kind of clock that was regulating the whole process. But back in the early days there were no resources to really help me build on that idea. Dr. Sears: I know what you mean… I thought that cell division was the key. I predicted 15 years ago that within about twenty years these ideas would mature into a real treatments that could impact telomere biology. Dr. Andrews: Exactly. When I received my Ph.D. in Molecular and Population Genetics back in 1981, I interviewed at dozens of universities looking for work in the field of aging. But I couldn’t find anything that was even remotely like what I wanted to do. So I went to San Francisco and started in the biotech industry. From there I was able to start my research in aging. Dr. Sears: What sparked your research of telomerase? Dr. Andrews: Back in the early 90s I attended one of the first conferences on anti-aging. While I was there I went to a lecture, which I think was called, “The science of aging,” or something like that. There I met Dr. Michael West who introduced me to the idea of telomere biology… and that’s when I had my “telomerase epiphany.” I thought, “Here’s what I’ve been looking for… and there was that idea of the clock again.” I told Michael if he hired me I would clone the telomerase gene in 3 months. And that’s exactly what I did. Together we became part of the newly formed Geron Corporation. From there I lead the team that cloned the RNA component of telomerase and then later the protein component. That was around 1993. Then in 1997 I was awarded 2nd place as “National Inventor of the Year.” Dr. Sears: I remember reading about it… I was following it closely. So what prompted you to leave Geron and go off on your own? Dr. Andrews: Geron was focused on using telomere biology to find a cure for cancer. They reasoned that if they could regulate telomerase they could use that technology to kill or deactivate cancer cells. I started Sierra Sciences to continue my search for a drug or supplement that would activate telomerase for the sake of rebuilding and lengthening the telomere. Dr. Sears: How did you feel when TA-Sciences developed TA-65, the first oral supplement that was able to activate telomerase? Dr. Andrews: I was thrilled. In fact, I was one of the first to take TA-65. And I paid full price, too! I was essentially taking part in an experiment and paying for the privilege. But I’m not complaining… TA-65 is a remarkable product. It really does work. To date, TA-65 is the only reliable way of turning on the gene that helps you rebuild your telomeres. When my lab tests came back the telomeres of my immune cells showed an increase in length. I consider that important as I feel the life of your immune cells is the most critical as it relates to longevity and anti-aging. Dr. Sears: That’s great news. I’ve been taking TA-65 for about three weeks now and I’ve also had good results. My vision has improved and so has my memory and power of recall. I feel like I have the physical endurance I did when I was in my 20s. The dramatic results shocked me. Dr. Andrews: I know what you mean. My vision improved too. In fact, I went to my optometrist and he actually had to reverse my prescription to make it weaker. I really notice it when I’m shaving in the morning and I don’t have my glasses on… I can stand straight up. I don’t have to lean in over the sink so that I can see my face. But the most remarkable effect I’ve experienced – and continue to experience – is physical endurance. I’m an ultra-marathon runner. I do one every month. These races are anywhere between 50 and 100 miles long. Now keep in mind… I’m 56 years old. Before I started taking TA-65, I was lucky just to finish. Now I’m winning events in my age class. It’s incredible. And when I finish these races I’m not even fatigued. I’m as strong at the finish line as I was when I started. It feels like I’ve just gone for a stroll in the park. I’m hooked on TA-65. I’ll never stop taking it… I’m afraid I’ll lose the incredible gains I get when I run. And all the tests show TA-65 has no toxicity whatsoever. It’s really very safe. Dr. Sears: And if you’re not fortunate enough to get TA-65, what can people do to slow the loss of the telomere? Dr. Andrews: I believe you know something about that… Dr. Sears: Well… yes. I’ve been working with my patients on this for years. Research shows a number of simple nutrients can slow the loss and damage of the telomere. This is largely connected to the idea that the build up of homocysteine – aside from being a major risk factor for heart attack and stroke – rapidly speeds up the loss of the telomere. You pointed out that telomere loss speeds up as your body accelerates cell division. But there are other factors that erode the telomere between cycles of division. And that’s where the average person can take a proactive stance. There’s a complex of B vitamins that effectively gets rid of excess homocysteine. My readers will know all about it. Vitamin C also slows the loss of the telomere. By as much as 65%... Dr. Andrews: Fascinating. It’s good to hear other doctors are working with this. Most doctors know nothing about it… And people need to know this. Short telomeres are unstable and this is dangerous. It triggers a rearrangement in the DNA, which causes the cell abnormalities that lead to cancer. Dr. Sears: How far will this technology take humanity? Dr. Andrews: When we fully understand telomere biology and the true mechanism of aging people will be living 250 years or longer… Dr. Sears: That’s encouraging, Bill. Thanks for sharing your story. I appreciate it. And I’m sure my readers will too. Dr. Andrews: Thanks for having me. NOTE from Dr. Sears: If you’re interested in TA-65 therapy, contact my office: 1-866-792-1035. I’m currently one of the only doctors in the US licensed to provide you with this cutting-edge therapy. In the meantime, there is one other step you can take to slow down the aging process, and even help to keep your telomeres longer and your cells younger: Keep your homocysteine levels in check. Homocysteine is an amino acid that accumulates in your tissues. It’s a natural byproduct of cell metabolism—think of it as a “waste product.” If your homocysteine levels are high, you’re at greater risk for Alzheimer’s, Parkinson’s, heart disease, and impotence. There’s a reason why: researchers have found that people with high homocysteine levels tripled the amount of telomere length that was lost during cell division.1 No wonder it’s linked to so many age-related diseases. You can measure your homocysteine levels with a simple blood test. And you can lower homocysteine naturally, without drugs. Here’s what you should take to keep it in check. You can find these nutrients at most health food stores or in my own homocysteine blocking formula. (Amounts are daily) Vitamin B12 – 500 mcg Folic Acid – 800 mcg Vitamin B6 – 25 mg Riboflavin (B2) – 25 mg TMG (trimethylglycine) – 500 mg ____________________ 1 Xu et al. “Homocysteine accelerates endothelial cell senescence.” FEBS Letters. 2000. 470:20-24
Knock Out Cancer Cells with this Powerful Amazon Berry Most days I drink a bit of a juice called açai (ah-SAH-ee). I sometimes recommend it to patients too. Here’s why: The açai berry is a very powerful antioxidant and a potent inflammation fighter. It’s a real powerhouse antioxidant packing 10 times the antioxidant power of cranberries. The ORAC value shows a food’s antioxidant power. The higher the ORAC value, the stronger its antioxidant power. The açai berry has an ORAC value of 102,700 (per 100 grams)!1 Before the açai berry, we used to think of blueberries and cranberries as being number one on the antioxidant list. But the açai berry is much stronger. This graph shows how dramatic the difference is: A number of studies at the Jean Mayer USDA Human Nutrition Research Center on Aging give good reason to believe that eating foods with a high ORAC (Oxygen Radical Absorbance Capacity) value may help slow the aging process in both your body and brain.2 In their studies, they found that eating plenty of high-ORAC foods:
Below is a table showing foods with high ORAC values.
University Tests Reveal Açai Berry’s Cancer Fighting Power…In one of the first landmark studies to investigate the health benefits of the açai berry, University of Florida researchers found something remarkable. When introduced to cancer cells, this popular Brazilian berry triggered a self-destruct response in up to 86% of leukemia cells tested.3 Cancer is what happens when damaged cells start to multiply out of control. And free radicals are a major contributor to cell damage. Free radicals are bad, unstable oxygen molecules. Typically, they are missing an electron and attack the nearest stable molecule, “stealing” its electron. When the “attacked” molecule loses its electron, it becomes a free radical itself, beginning a chain reaction. Once this chain reaction begins it has a snowball effect. Antioxidants neutralize free radicals by donating one of their own electrons, ending the electron-“stealing” reaction. The antioxidant molecules themselves don’t become free radicals because they donated an electron – they are stable in either form. Antioxidants help to prevent cell and tissue damage that could lead to cellular damage and disease. That’s why the açai berry is a powerful cancer fighter. It has a rich source of antioxidants that protect every one of your body’s cells, tissues, and organs. In addition to helping prevent cancer, antioxidants reduce inflammation – a major cause of diseases like Alzheimer’s, heart disease, and arthritis. Plus, they boost your immune system and ensure your organs function properly. Açai is naturally rich in:
The açai berry is one of the most powerful antioxidants you’ll find in fresh fruits. I am so impressed with it that I’m looking into putting it in a new antioxidant supplement. And there are other fruits that pack a serious antioxidant punch… Here are a few of my favorites: Fight Free Radicals with these 4 Little-Known Antioxidants• Bromelain – This is a protein-digesting enzyme that comes from the stem of the pineapple plant. It reduces harmful prostaglandins which cause inflammation – especially in joints. Numerous studies prove its effectiveness at relieving pain from arthritis.4 Plus, it works synergistically and amplifies the effects of other antioxidants. Take 500 mg once a day for optimal protection. • Camu Camu Extract – This extract comes from a reddish purple cherry that grows deep within the Amazon Rainforest. It boasts the highest natural vitamin C content of any food in the world –over 30 times the vitamin C found in an orange. It’s also a rich source of anthocyanins. These are potent antioxidants that seek and destroy harmful free radicals. In fact, a study published in the Journal of Agricultural and Food Chemistry found anthocyanins to be effective at inhibiting the growth of human tumor cells.5 Take 400 mg daily. • Pomegranate Juice – Pomegranate juice contains a whole array of antioxidants. But its most powerful is punicalagin. It protects cardiovascular function and helps your cells replicate properly. In a recent study, punicalagin was shown to stop the spreading of colon cancer cells.6 You can find pomegranate juice at your local health food store. • Goji Berry – For over 6,000 years, Chinese and Tibetan herbalists have used Goji berries to protect the liver, improve eyesight, boost the immune system, and improve circulation. They look like red raisins and are packed with antioxidants known as carotenoids. You can find them at a Chinese herbal shop or your local health food store. Eat 3 berries a day or drink 2 tablespoons of Goji berry juice mixed in water or your favorite juice. 1 Press Release. USDA, “Oxygen Radical Absorbance Capacity (ORAC) of Selected Foods – 2007” Nov. 2007 2 www.ars.usda.gov/is/AR/archive/feb99/aging0299.htm 3 Del Pozo-Insfran, D.; Percival, S. S.; Talcott, S. T. “Açai (Euterpe oleracea Mart.) Polyphenolics in Their Glycoside and Aglycone Forms Induce Apoptosis of HL-60 Leukemia Cells” J. Agric. Food Chem.; (Article); 2006; 54(4); 1222-1229. 4 Brien, S. “Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies” Evid Based Complement Alternat Med. 2004 December; 1(3): 251–257. 5 Meiers S. The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. J Ag Food Chem. 2001 Feb 19;49(2):958-62. 6 Heber, D, et al. “Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells.” J Agric Food Chem. 2006 Feb 8;54(3):980-5.
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