When I was in medical school, they never told me about the hormone leptin. They didn’t even know it existed.
Then the medical community widely accepted the view that leptin was a new potential avenue to control obesity because it would stop your hunger. Some even went as far as suggesting that we should give everyone who was overweight a leptin injection.
Now we find out it’s not what we thought it was. Leptin should control hunger. But when you gain too much weight you become leptin resistant. Your brain will then ignore leptin’s signals. Giving people more leptin will only make it worse.